25 July 2025 | Dr Nicole Rous (BVSc (Hons))
Allergies in Pets: Unpacking the Immune Imbalance Beneath the Itch

If your dog or cat suffers from constant scratching, licking, redness or recurring ear infections, allergies may be at play. But what many pet parents don’t realise is that these surface symptoms often reflect something deeper: immune dysregulation. While symptom relief has its place, true progress comes from understanding what’s happening inside the body - particularly in the gut and immune system.

What Is Atopy and Why Is It So Common?

Canine atopic dermatitis is one of the most common chronic skin conditions in dogs. It’s an inflammatory, genetically linked condition triggered by environmental substances like pollen, dust mites or mould. In cats, allergic reactions may present as facial itching, overgrooming or ear inflammation.

We now know that atopy isn’t just “skin-deep.” Many affected pets also show signs of altered skin and gut microbiomes - pointing to a systemic condition.

A 2020 study in Frontiers in Veterinary Science found that diet and microbiome composition strongly influence the progression and severity of canine atopic dermatitis

The Gut-Skin-Immune Axis

Your pet’s gut is home to trillions of microbes that play a major role in immune regulation. When the microbiome is disrupted, by antibiotics, processed food, stress or illness, it can lead to leaky gut and increased inflammation throughout the body.

The skin often becomes the “warning light” for this internal imbalance. Research shows that pets with allergies frequently have reduced microbial diversity and signs of gut inflammation.

One review in Veterinary Clinical Pathology confirms this link, showing that microbial imbalance in the gut contributes to increased allergic sensitivity on the skin.

Food or Environmental Allergy? Or Both?

Environmental allergens like grasses and dust mites are often blamed for flare-ups, but food sensitivities can also be contributing behind the scenes, especially when symptoms are year-round, affect the gut, or don't improve with environmental management alone. To clarify the picture, our upcoming allergy panels will help identify:

  • Sensitivity to common environmental triggers
  • Food-related reactions to proteins or additives
  • Inflammatory patterns linked to gut dysbiosis

This data allows us to move from reactive treatments to informed, targeted care.

Why Guessing Isn’t Good Enough

Rather than relying on elimination diets or repeated courses of medication, testing can provide objective answers.

Through microbiome and allergy screening, we can uncover:

  • Gut imbalances that amplify immune reactivity
  • Signs of intestinal inflammation or poor digestion
  • Specific sensitivities that are keeping your pet in flare-up mode

Armed with this information, pet parents can feel confident in the plan ahead and track real progress over time.

A Whole-Body Approach to Allergy Relief

Managing allergies effectively means supporting the gut, calming the immune system and rebuilding the skin barrier. Our integrative approach includes:

  • Prebiotics and probiotics to rebalance gut flora
  • Anti-inflammatory nutrients like omega-3s and zinc
  • Nutrition plans that eliminate triggers and support healing
  • Strategies to reduce environmental exposure
  • Regular re-testing to assess improvement

This layered approach not only reduces symptoms but also builds long-term resilience.

Final Thoughts

Allergies in pets are complex, and chronic itching is only the tip of the iceberg. Immune imbalance, gut dysfunction and barrier breakdown often sit at the core. When we move beyond symptom control and uncover what’s really driving the reaction, we can finally help pets feel comfortable in their own skin again.

Image of Dr Nicole Rous (BVSc (Hons))
Dr Nicole Rous (BVSc (Hons))
Amelia is passionate about Australia's preventive health agenda having worked with some of the world's largest pharmaceutical companies. Amelia moved to Perth 10 years ago where she founded i-screen to democratise pathology and open access to the health data that really matters.
References:
  • Anturaniemi, J., Zaldívar-López, S., Savelkoul, H. F. J., Elo, K., & Hielm‑Björkman, A. (2020). The effect of atopic dermatitis and diet on the skin transcriptome in Staffordshire Bull Terriers. Frontiers in Veterinary Science, 7, Article 552251.
  • Feigin, V. L., Norrving, B., Mensah, G. A., Michel, P., Roth, G. A., Bisht, M., Barker-Collo, S. L., Davis, S., Hackett, M. L., Kernick, D., Lee, J. M., Leahy, S. M., & Pandian, J. D. (2022). Update to the global burden of stroke and mortality by risk factors: GBD 2019, 2020, and 2021 data. Frontiers in Neurology, 13, Article 9292158.
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This information is not intended to be a substitute for professional medical advice. Always seek the guidance of your veterinarian practitioner or other qualified health professional with any questions you may have regarding your pet's health or a medical condition.
© 2025 Intelligent Screening Pets (Pty) Ltd, Australia